CBD For Fighting Cancer

Cancer and uncontrolled cell development related diseases were responsible for 600,000 deaths just in the USA in 2017. Cancer, by definition, is any cell found in the human body that has uncontrolled growth and actively invades the host with its spread. With that uncontrolled cell development comes inflammation and compression of nearby tissue and organs causing unrelenting and disabling pain.  Traditional treatments for Cancer are chemotherapy and radiation therapy; both of which also can cause irritation and breakdown of solid and healthy tissue alongside the tumorous disease cells. Recent research suggests that Cannabinoids (CBD) may prevent cancer cell growth and reducing the ability of tumor cells to reproduce.

What is CBD?

The cannabis plant contains more than 100 different chemical compounds known as cannabinoids, which interact with the body’s endocannabinoid system. Cannabidiol or CBD is the most famous among them for having hundreds of medical benefits.

So, Cannabidiol—CBD—is a cannabis compound that has remarkable medical and recreational benefits, but does not make people feel “High”. It can actually prevent the psychoactivity of THC. Cannabidiol is one of at least 113 active cannabinoids identified in cannabis. It is a major phytocannabinoid, accounting for up to 40% of the plants extract. The fact is that CBD-infused cannabis strains are non-psychoactive or less psychoactive than THC-dominant strains. It’s made CBD products a good option for patients looking for relief from inflammation, pain, anxiety, psychosis, seizures, spasms, and other conditions without disconcerting feelings of lethargy or dysphoria.

What you will find in this article is reference to numerous scientific studies that all are visible on governmental sites.

What Is Cancer

Cancer is not one disease, but the name given to a collection of related diseases characterized by an abnormal growth of cells. There are more than 100 different types of cancer that are caused by both external factors (such as smoking, viruses, or carcinogens) and genetic factors (such as genetic mutation inherited from one’s parents). Trillions of cells compose the human body, meaning cancer could start anywhere.

Like humans, cells grow old or become damaged and eventually die. Other cells grow and divide to form new ones to replace these old and damaged cells, but when cancer develops, abnormal cells including the old and damaged ones survive even though they should die. Some of the body’s cells will start to divide interminably and spread into surrounding tissues, creating new cancerous cells that aren’t needed. And since these new cells won’t stop growing and dividing, they are likely to hide in the immune system and form abnormal growths like masses of tissue known as tumors.

Cancerous tumors can spread into and invade nearby tissues because they’re malignant. Although they can be removed, these tumors are likely to grow back. As tumors grow, cancer cells can break off and travel through the blood or the lymph system to any other part of the body to form new tumors.  Often far away from the original source. This process is known as metastasis.

Benign tumors, on the other hand, don’t spread to or invade nearby tissue and won’t grow back after being removed. Unfortunately, benign tumors in the brain can be life-threatening.

Cancer (and its treatments) leaves its host feeling weak and dizzy. Symptoms may differ depending on where in the body the cancer is located, but may include:

  • Blood in urine or stools
  • Bruising
  • Changes in genitalia
  • Coughs lasting more than a month or accompanied by blood
  • Depression
  • Difficulty breathing
  • Difficult bowel movements
  • Discomfort after eating
  • Fever
  • Fatigue
  • Heartburn
  • Lumps or swelling
  • Persistent indigestion
  • Night sweats
  • Spots and growths on the skin or changes in size, shape, and color of an already-existing mole like yellowing, darkening, or redness
  • Sores that won’t heal
  • Weight loss
  • Weight gain
  • Unexplained bleeding
  • Unexplained joint pain

CBD and Breast Cancer

A standout amongst the most exciting areas of current cannabinoid research field is the investigation of the potential use of CBD as antitumor medications. CBD is the main nontoxic exogenous operator that may essentially reduce Id-1 expression in metastatic breast cancer cells prompting the down-control of tumor aggressiveness [1][2]. The CBD concentrations is powerful at restraining Id-1 expression corresponded with those used to inhabit the proliferative and obtrusive phenotype of breast cancer cells. Of the five cannabinoids tried: cannabidiol, cannabigerol, cannnabichromene; cannabidiol-acid and THC-acid, it was discovered that cannabidiol (CBD) may be the most powerful inhibitor of cancer cell development [3].

CBD and Lung Cancer

Studies demonstrate that Δ9-tetrahydrocannabinol found in CBD has been known to decrease tumor development, number of tumors, and the amount of lung cavity[4]. CBD prompts ICAM-1, and thereby causing TIMP-1 induction and subsequently may decrease cancer cell development in lungs [5].

Non-small cell lung cancer (NSCLC) is the main cause (approx. 50%) of death in lung cancer in the world. Researchers have also proven that the treatment of NSCLC cell lines (A549 and SW-1573) with CB1/CB2-and CB2-particular agonists Win55, 212-2 and JWH-015, respectively, altogether may weaken the intensity of random malignancy growth in vitro chemotaxis and chemo-invasion in these cells [6]. Scientists also observed critical reduction in focal adhesion complex, which plays a major role in cancer migration. CBD may suppress tumor          development and lung metastasis (to almost ∼50%) [7].

CBD and Pancreatic Cancer

Recent studies on pancreatic Cancer showed that CBD increases the apoptosis rate of pancreatic tumor cells by means of a CB2 receptor and de novo synthesized ceramide-dependent up-regulation process of p8 and the endoplasmic reticulum stress– related genes ATF-4 and TRB3. These discoveries added the reason for rethinking CBD as a promising option for treating pancreatic Cancer by the National Cancer Institute [8].

CBD and Prostate Cancer:

Prostate cancer cells basically expand by the high abnormal expression of both CB1 and CB2 receptors, and CBD may result in decreasing cancer cell sustainability, expanded apoptosis rate, and lessened abnormal expression in these receptors expression and also may decrease prostate-specific antigen excretion[9].

CBD and Leukemia and Lymphoma

Various studies on human leukemia and lymphoma cells show that after stimulated by CBD, CB1 and CB2 receptors serve our the immune system quite well and work as a potential target finder for apoptosis to begin in malignancy affected cell line. Our CB2 receptors work pretty well after treated by cannabinoids like THC and CBD as an active anti-cancer agent but it works best without psychotropic effects. So in this case CBD may be ideal particularly to target and kill leukemia cells. CBD may also increase the rate of healthy blood cell production in our bone marrow system.

CBD-treated malignancies and tumors displayed an increased number of apoptotic cells with a decreased expression of proangiogenic factors like VEGF a potential tumor growth factor for lymphoma. These outcomes indicate CBD as a helpful approach for the treatment of skin tumors [10] [11] [12].

CBD in Cancer Treatment – Summary

Many scientific research and studies in Cancer already proved that CBD may be highly effective in treating other rare types of cancer like Cervical Cancer [13], Hepatocellular carcinoma [14], skin and throat cancer. So the effectiveness of CBD as a powerful anti-cancer agent can be summarized below.

# Activating a powerful cancer cell damage mechanism called apoptosis.

# May prevent cancer affected cells from dividing and spreading into healthy tissues

# May prevent new blood vessels from turning in tumors.

# May accelerat the cell’s inside ‘waste disposal mechanism’ by triggering a process called autophagy. which increases the apoptosis in cancer affected cells.

Few Revolutionary Medical Research and Studies on CBD and Cancer

Cannabis has been the subject of various cancer research studies over the last 20 years. Here is some honorable mentions emphasizing CBD in cancer treatment.

Crosstalk between chemokine receptor CXCR4 and cannabinoid receptor CB2 in modulating breast cancer growth and invasion. Nasser MW; et al; PLoS One. 2011;6(9):e23901. doi: 10.1371/journal.pone.0023901. Epub 2011 Sep 7; http://www.ncbi.nlm.nih.gov/pubmed/21915267.

Cannabinoids: a new hope for breast cancer therapy?

Caffarel MM et al; Cancer Treat Rev.: 2012 Nov; 38(7):911-8. doi: 10.1016/j.ctrv.2012.06.005. Epub 2012 Jul 7; http://www.ncbi.nlm.nih.gov/pubmed/22776349.

“Cannabinoids Induce Apoptosis of Pancreatic Tumour Cells via Endoplasmic Reticulum Stress–Related Genes” (Cancer Research, 2006)

“Cannabis-based medicine reduces multiple pathological processes in A?PP/PS1 mice” (Journal of Alzheimer’s Disease, 2015)

“Inhibition of skin tumour growth and angiogenis in vivo by action of cannabinoid receptors” (Journal of Clinical Investigation, 2003)

The role of cannabinoids in prostate cancer: Basic science perspective and potential clinical applications;Juan A. Ramos and Fernando J. Bianco; Indian J Urol. 2012 Jan-Mar; 28(1): 9–14;.doi:10.4103/0970-1591.94942;  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339795/?report=classic

Delta9-tetrahydrocannabinol-induced apoptosis in Jurkat leukemia T cells is regulated by translocation of Bad to mitochondria.

Jia W et al; Mol Cancer Res.; 2006 Aug;4(8):549-62; http://www.ncbi.nlm.nih.gov/pubmed/16908594

Cannabinoids – a new weapon against cancer?  BY Pokrywka M1, Góralska J1, Solnica B1.

Closing Thoughts

CBD can help you on the off chance that you are a cancer patient who does not say “we have done whatever we can do” to heart, but always keep the spirit and believe fighting this deadly disease. As mentioned above, numerous scientific studies and researches prove that CBD can be an ideal option for cancer patients. With safe, high quality and natural CBD products we are here to provide you a safe and standard cancer free living in. Visit us today at Whole CBD Choice.

References

[1] Crosstalk between chemokine receptor CXCR4 and cannabinoid receptor CB2 in modulating breast cancer growth and invasion. Nasser MW; et al; PLoS One. 2011;6(9):e23901. doi: 10.1371/journal.pone.0023901. Epub 2011 Sep 7; http://www.ncbi.nlm.nih.gov/pubmed/21915267.

[2] Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells; McAllister SDet al; Mol Cancer Ther. 2007 Nov;6(11):2921-7;  http://www.ncbi.nlm.nih.gov/pubmed/18025276.

[3] Delta9-tetrahydrocannabinol inhibits cell cycle progression in human breast cancer cells through Cdc2 regulation; Caffarel MM et al;

Cancer Res;

2006 Jul 1;66(13):6615-21; http://www.ncbi.nlm.nih.gov/pubmed/16818634

[4] Cannabinoids: a new hope for breast cancer therapy?

Caffarel MM et al; Cancer Treat Rev.: 2012 Nov; 38(7):911-8. doi: 10.1016/j.ctrv.2012.06.005. Epub 2012 Jul 7; http://www.ncbi.nlm.nih.gov/pubmed/22776349

[5] Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1.Ramer R et al; FASEB J.; 2012 Apr;26(4):1535-48. doi: 10.1096/fj.11-198184. Epub 2011 Dec 23; http://www.ncbi.nlm.nih.gov/pubmed/22198381?dopt=Abstract

[6] Cannabinoid receptors, CB1 and CB2, as novel targets for inhibition of non-small cell lung cancer growth and metastasis; Preet A, et al; Cancer Prev Res (Phila). 2011 Jan;4(1):65-75. doi: 10.1158/1940-6207.CAPR-10-0181. Epub 2010 Nov 19; http://www.ncbi.nlm.nih.gov/pubmed/21097714?dopt=Abstract

[7] Δ9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo; A Preetet al; Oncogene; (2008) 27, 339–346; doi:10.1038/sj.onc.1210641; published online 9 July 2007;  http://www.nature.com/onc/journal/v27/n3/abs/1210641a.html

[8] https://www.cancer.gov/about-cancer/treatment/cam/hp/cannabis-pdq#section/all

[9] The role of cannabinoids in prostate cancer: Basic science perspective and potential clinical applications;Juan A. Ramos and Fernando J. Bianco; Indian J Urol. 2012 Jan-Mar; 28(1): 9–14;.doi:10.4103/0970-1591.94942;  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339795/?report=classic

[10] Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease.

McKallip RJ et al; Blood. 2002 Jul 15;100(2):627-34.; http://www.ncbi.nlm.nih.gov/pubmed/12091357

[11] Delta9-tetrahydrocannabinol-induced apoptosis in Jurkat leukemia T cells is regulated by translocation of Bad to mitochondria.

Jia W et al; Mol Cancer Res.; 2006 Aug;4(8):549-62; http://www.ncbi.nlm.nih.gov/pubmed/16908594.

[12] Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors.

Casanova ML et al: J Clin Invest. 2003 Jan;111(1):43-50; http://www.ncbi.nlm.nih.gov/pubmed/12511587

[13] Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1; Ramer Ret al; Biochem Pharmacol; 2010 Apr 1;79(7):955-66. doi: 10.1016/j.bcp.2009.11.007. Epub 2009 Nov 13; http://www.ncbi.nlm.nih.gov/pubmed/19914218

[14] Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy. Vara D et al.

Leave a Comment

Your email address will not be published. Required fields are marked *

Solve : *
24 ⁄ 6 =